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目的研究石榴皮水提物(AEPP)对束缚-浸水应激(简称应激)大鼠胃肠运动的影响。方法 Wistar雄性大鼠随机分为空白对照组、对照Ⅰ组(三蒸水)、对照Ⅱ组(三蒸水+应激)、对照Ⅲ组(5000mg.kg-1除多酚AEPP+应激)和实验Ⅰ、Ⅱ、Ⅲ(50,500,5000 mg.kg-1AEPP+应激)组,观察其胃溃疡指数和胃肠的运动。结果与对照Ⅱ组比较,实验Ⅱ、Ⅲ组的胃黏膜损伤指数明显减少,胃内残留率明显增多,小肠推进率明显降低,排便时间明显延长(均P<0.05,P<0.01)。结论石榴皮多酚对应激性胃黏膜损伤、胃肠道运动机能紊乱有良好的预防作用。
Objective To study the effect of water extract of pomegranate peel (AEPP) on gastrointestinal motility in restraint-flooding stress rats. Methods Wistar male rats were randomly divided into blank control group, control group Ⅰ (three distilled water), control group Ⅱ (triple distilled water + stress), control group Ⅲ (5000mg.kg-1 addition of polyphenol AEPP + stress) Experiments Ⅰ, Ⅱ, Ⅲ (50, 500, 5000 mg.kg-1EPP + stress) group were observed gastric ulcer index and gastrointestinal motility. Results Compared with the control group Ⅱ, the gastric mucosal lesion index, the gastric residual rate and the small intestine propulsion rate were significantly decreased (P <0.05, P <0.01). Conclusion Pomegranate peel polyphenols have a good preventive effect on gastric mucosal injury and gastrointestinal motility disorders.