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目的探讨慢性阻塞性肺病(COPD)急性加重期胆碱酯酶和降钙素原的水平变化。方法选取2014年3月—2016年2月青岛市第八人民医院收治的127例慢性阻塞性肺病急性加重期患者作为观察组,选取100例同期健康体检者作为对照组,观察2组血清中胆碱酯酶(CHE)、降钙素(PCT)水平;对观察组患者进行吸氧、化痰、平喘、改善通气、抗感染等常规治疗,并加用痰热清注射液20 ml加入5%葡萄糖注射液中静脉输注,1次/d,7 d为1个疗程。比较治疗前后患者血清中CHE、PCT水平的变化。采用SPSS19.0统计学软件及t检验分析数据。P<0.05为差异有统计学意义。结果 COPD急性加重期患者血清中CHE水平低于对照组,PCT水平高于对照组,差异均有统计学意义(P<0.05);治疗后COPD急性加重期患者血清中CHE水平高于治疗前,PCT水平低于治疗前,差异有统计学意义(P均<0.05)。结论 COPD急性加重期患者血清CHE水平降低,PCT水平升高;治疗后CHE水平升高、PCT水平降低。
Objective To investigate the changes of cholinesterase and procalcitonin in patients with chronic obstructive pulmonary disease (COPD) exacerbation. Methods A total of 127 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) admitted from the Eighth People’s Hospital of Qingdao from March 2014 to February 2016 were selected as the observation group and 100 healthy subjects were enrolled as the control group. (CHE) and calcitonin (PCT). The patients in the observation group were given conventional therapy including oxygenation, phlegm, asthma, ventilation and anti-infection, and added with 20 ml of Tanreqing Injection % Glucose injection intravenous infusion, 1 / d, 7 d for a course of treatment. The serum levels of CHE and PCT in patients before and after treatment were compared. Using SPSS19.0 statistical software and t test to analyze the data. P <0.05 for the difference was statistically significant. Results The level of CHE in serum of patients with acute exacerbation of COPD was lower than that of control group, PCT level was higher than that of control group (P <0.05) PCT levels were lower than before treatment, the difference was statistically significant (P all <0.05). Conclusions Serum levels of CHE decreased and PCT levels increased in patients with acute exacerbation of COPD. CHE level increased and PCT level decreased after treatment.