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利用紫外-可见吸收光谱(UV-Vis)、核磁共振(1HNMR)、红外光谱(FTIR)研究了1,4-二羟基蒽醌(DHA)与Y3+的配位作用,结果表明Y3+与DHA能形成物质的量之比为1:1的一维链状配位聚合物Y-DHA.与DHA相比,Y-DHA在可见光区的吸收大幅增强,同时具有良好的水溶性.紫外-可见吸收光谱、荧光光谱及DNA熔链温度实验研究结果表明,Y-DHA与CTDNA可通过静电作用和沟槽结合的方式结合,而DHA与CTDNA的作用方式主要为沟槽结合.循环伏安法表明,Y-DHA的还原电位(-0.324VvsSCE)要高于DHA的还原电位(-0.387VvsSCE).无氧条件下,Y-DHA光损伤DNA的能力要明显高于DHA.
The coordination of 1,4-dihydroxyanthraquinone (DHA) with Y3 + was studied by UV-Vis, 1HNMR and FTIR. The results showed that Y3 + and DHA could form Y-DHA, a one-dimensional chain coordination polymer with 1: 1 ratio of the amount of material, exhibits a much stronger absorption in the visible region than DHA, and has good solubility in water.Ultraviolet-Visible Absorption Spectroscopy , Fluorescence spectra and DNA melting temperature experimental results show that, Y-DHA and CTDNA by electrostatic interaction and groove binding manner, and DHA and CTDNA mode of action is mainly groove binding. Cyclic voltammetry shows that, Y The reduction potential of -DHA (-0.324V vsSCE) was higher than that of DHA (-0.387V vsSCE). Under anaerobic conditions, the ability of Y-DHA to damage DNA was significantly higher than that of DHA.