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目的监测兔急性肺血栓栓塞症(PTE)后TNF-α、IL-4和IL-8的水平的变化;探讨炎症因子与肺损伤的关系。方法将实验兔子随机分为对照组、模型组,选取不同的时间点抽血化验,ELISA方法检测血清,术毕行病理分析。结果 (1)栓塞后TNF-α及IL-8水平明显高于对照组,栓塞后4h达高峰。IL-4在发病早期未见升高,而在栓塞后6h明显升高,P值﹤0.05,差异有统计学意义。(2)病理结果栓塞后肺动脉内血栓形成,组织萎缩、出血、炎性反应明显。结论急性PTE后炎症因子发生的不同变化,在引起急性肺损伤中起重要作用。
Objective To investigate the changes of TNF-α, IL-4 and IL-8 levels after acute pulmonary thromboembolism (PTE) in rabbits and to explore the relationship between inflammatory cytokines and lung injury. Methods Experimental rabbits were randomly divided into control group and model group. Blood samples were taken at different time points and serum was detected by ELISA. Results (1) The levels of TNF-α and IL-8 after embolization were significantly higher than those of the control group, reaching the peak at 4h after embolization. IL-4 in early onset did not increase, but significantly increased 6h after embolization, P value <0.05, the difference was statistically significant. (2) pathological results thromboembolism after pulmonary embolism, tissue atrophy, bleeding, inflammatory response was significant. Conclusion Different changes of inflammatory factors after acute PTE play an important role in causing acute lung injury.