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高效抗逆转录病毒治疗(HAART)引入艾滋病的临床后,HAART可以使很多艾滋病病毒(HIV)患者的病毒载量下降、CD4水平升高和免疫重建,但是单纯HAART不能根治HIV感染。不能根治的关键是持续存在的HIV病毒储存库。按照HIV储存库的“流入流出”理论,消减HIV储存库的方法只有两个:减少来源和促进静止细胞活化、流出储存库。因此免疫治疗在HAART治疗的后时代被提上研究日程,持续有效地增加储存库流出速率才是消减储存库总量,最终达到“临床治愈”HIV感染的有效办法。白细胞介素2、6、7(IL-2I、L-6I、L-7)和抗CD3抗体、肿瘤坏死因子-α、组蛋白去乙酰酶抑制剂、Prostratin、微小RNAs、免疫毒素,都是目前研究的HIV免疫治疗方法。其中IL-2I、L-7、Prostatin能有效激活储存库细胞。对于HIV免疫治疗方案,其有效性和治疗能维持时间的长短同等重要。
After HAART is introduced into the AIDS epidemic, HAART can reduce the viral load, CD4 level and immune reconstitution of many HIV patients, but HAART alone can not cure HIV infection. The key to failure to cure is the persistence of HIV virus repositories. According to the “influxes / outflows” theory of HIV repositories, there are only two ways to reduce HIV repositories: reducing sources and promoting quiescent cell activation and outflow of storage. Therefore, the immunotherapy is put on the research agenda in the post-HAART era. Continued and effective increase of bank outflow rate is the effective way to reduce the total stock of the depot and eventually achieve “clinically cured” HIV infection. Interleukin 2, 6, 7 (IL-2I, L-6I, L-7) and anti-CD3 antibodies, tumor necrosis factor-alpha, histone deacetylase inhibitors, Prostratin, microRNAs, The current study of immunotherapy with HIV. Among them IL-2I, L-7, Prostatin can effectively activate the reservoir cells. For HIV immunotherapy programs, their effectiveness and duration of treatment can be as important as the length of time.