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一些时候以来,已认识到甲状腺激素可不同程度地影响淋巴细胞的新陈代谢。在体内,甲状腺激素与肾上腺皮质激素之间似乎有明显的相互作用,这种相互作用使人们难于解释甲状腺激素所致的任何直接的免疫学效应。作者发现,对鸟类进行有效的短期甲状腺阻滞,可阻止其对抗原(绵羊红细胞)产生体液免疫应答。直到阻滞解除后,体液免疫应答才又恢复。与对照组相比,阻滞解除后随即出现抗体合成异常增高。阻滞时抗体合成受抑制的程度与硫脲类诱导的T_3抑制的程度有直接关系。上述结果也见于鼠的实验模型。
It has been recognized for some time that thyroid hormones affect lymphocyte metabolism to varying degrees. There appears to be a clear interaction between thyroid hormones and adrenal cortical hormones in the body, an interaction that makes it difficult to interpret any direct immunological effects of thyroid hormones. The authors found that effective short-term thyroid blockade of birds prevented their production of a humoral immune response to the antigen (sheep erythrocytes). Until the release of the block, humoral immune response was restored. Compared with the control group, there was an abnormal increase of antibody synthesis immediately after the block was released. The extent of inhibition of antibody synthesis during blockade is directly related to the extent of thiourea-induced T 3 inhibition. The above results are also found in the rat experimental model.