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目的评价急进不同海拔高原使用氧疗预防急性高原病(AMS)的效果。方法 238名和117名男性青年分别进入海拔4300 m和5400 m驻地后,依据《急性高原反应的诊断和处理原则》调查AMS症状并评分,总分>5分者作为研究对象,并随机分成氧疗组和对照组。从第2 d上午11时开始,氧疗组以2 L/min吸氧,2 h/d;对照组不吸氧。每天下午检测研究对象心率和血氧饱和度,调查匹兹堡睡眠质量指数(PSQI)和AMS症状评分并计算总分,连续7 d。结果与对照组比较,4300 m氧疗组第2~4 d时AMS症状总分降低,第2~5 d时HR降低,第2~8 d时PSQI总分降低(P<0.05或P<0.01),Sa O2无统计学差异(P>0.05)。与对照组比较,5400 m氧疗组第2~8 d时AMS症状总分、HR降低和PSQI总分均降低,而Sa O2升高(P<0.05或P<0.01)。结论吸氧能明显减轻急性高原病症状,改善其睡眠状况;急进4000 m左右建议吸氧3~4 d,而急进5000 m以上应连续吸氧≥7 d。
Objective To evaluate the effect of using oxygen therapy to prevent acute mountain sickness (AMS) in different altitudes. Methods 238 and 117 male adolescents entered the stations of 4300 m and 5400 m above sea level respectively. According to the principle of diagnosis and treatment of acute altitude sickness, AMS symptoms were scored and score> 5 points were randomly divided into oxygen therapy Group and control group. From 11:00 on the 2nd day, the oxygen therapy group received oxygen at 2 L / min for 2 h / d, while the control group did not receive oxygen. Subjects were tested daily for heart rate and oxygen saturation. Pittsburgh Sleep Quality Index (PSQI) and AMS symptom scores were scored and scored for a total of 7 consecutive days. Results Compared with the control group, the total score of AMS decreased from 2 to 4 d in 4300 m oxygen therapy group, HR decreased from 2 to 5 d, and decreased from 2 to 8 d (P <0.05 or P <0.01) ), Sa O2 no statistical difference (P> 0.05). Compared with the control group, the scores of AMS symptom score, HR and PSQI score decreased on the 2nd to 8th day in the 5400 m oxygen therapy group, while Sa O2 increased (P <0.05 or P <0.01). Conclusion Oxygen inhalation can obviously relieve the symptoms of acute altitude sickness and improve its sleeping condition. It is suggested that the oxygen uptake of 4000 m is about 3-4 days, while the acute oxygen intake of more than 5000 meters should be continuous oxygen ≥7 days.