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目的观察自拟解毒抗癌经验汤剂、西妥昔单抗联合化疗对晚期结肠癌患者免疫功能及生活质量的影响。方法将94例晚期结肠癌患者随机均分为两组。对照组给予FOLFIRI方案化疗,观察组则加用自拟解毒抗癌经验汤剂、西妥昔单抗治疗。观察近期临床疗效及用药安全性,对比两组治疗前后的疼痛NRS评分及生活质量KPS评分,检测患者血清癌胚抗原(CEA)、炎性因子水平变化,检测免疫功能相关指标T淋巴细胞亚群的水平变化。结果观察组的近期疗效显著优于对照组,其疼痛NRS评分显著低于对照组,而生活质量KPS评分则显著高于对照组,差异具有统计学意义(P<0.05);观察组CEA、IL-1β、IL-6水平经治疗后均显著降低,明显低于对照组,差异具有统计学意义(P<0.05);观察组与机体免疫相关的CD8~+水平显著低于对照组,CD4~+、CD4~+/CD8~+水平显著高于对照组,差异均具有统计学意义(P<0.05);观察组胃肠不适、神经毒性、白细胞下降3方面的不良反应显著低于对照组,差异显著(均P<0.05),其余不良反应无显著差异(P>0.05)。结论采用中西医结合联合化疗法有利于减轻晚期结肠癌患者的疼痛,提高生活质量,减毒增效作用突出,其机制与提高机体免疫功能、调控肿瘤因子CEA水平有一定相关性。
Objective To observe the influence of self-detoxification and anti-cancer experience decoction and cetuximab combined with chemotherapy on immune function and quality of life in patients with advanced colon cancer. Methods 94 patients with advanced colon cancer were randomly divided into two groups. The control group was given FOLFIRI regimen chemotherapy, while the observation group was treated with self-detoxification anti-cancer decoction and cetuximab. The clinical efficacy and medication safety were observed. The pain NRS score and quality of life KPS score were compared between the two groups before and after treatment. The levels of serum carcinoembryonic antigen (CEA) and inflammatory cytokines were measured before and after treatment. T lymphocyte subsets The level of change. Results The short-term curative effect of the observation group was significantly better than that of the control group. The pain NRS score was significantly lower than that of the control group, while the KPS score of quality of life was significantly higher than that of the control group (P <0.05) (P <0.05). The levels of CD8 + in the observation group were significantly lower than those in the control group, and the levels of CD4 ~ +, CD4 ~ + / CD8 ~ + were significantly higher than those in the control group (P <0.05). Adverse reactions in gastrointestinal discomfort, neurotoxicity and leukopenia in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in other adverse reactions (P> 0.05). Conclusion Integrative treatment with traditional Chinese and western medicine is beneficial to relieve the pain of patients with advanced colon cancer and improve the quality of life. The attenuated and synergistic effect is prominent. The mechanism is related to the improvement of immune function and the regulation of CEA level.