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目的 探讨矽肺患者的肾脏功能状况。方法 采用放射免疫分析法测定了 99例矽肺患者和 30例正常对照人群尿白蛋白、β2 -微球蛋白。结果 矽肺患者尿白蛋白、β2 -微球蛋白均显著高于对照组 ,且与接尘时间长短相关。结论 二氧化硅粉尘可导致接触者慢性肾功能损害。
Objective To investigate the renal function of patients with silicosis. Methods The urinary albumin and β2 - microglobulin in 99 patients with silicosis and 30 normal controls were determined by radioimmunoassay. Results The urinary albumin and β2 - microglobulin in patients with silicosis were significantly higher than those in the control group, and were related to the duration of dust collection. Conclusion Silica dust can cause chronic renal impairment in contact.