近十年来,具有部位特异性的药物释放系统已受到关注。它不仅能提高药物的有效性,还能减小其对组织的毒性。药物释放系统一般可分为载体系统,机械泵或前体药物,而载体系统又主要为大分子药物释放系统,颗粒系统和细胞药物载体。聚合物前体药物则属于大分子药物释放系统,药物以共价键与聚合物骨架连接,在体内经生物转化而释放出药物产生疗效。 For the past decade, site-specific drug delivery systems have drawn attention. It not only improves the effectiveness of the drug but also reduces its toxicity to the tissue. Drug delivery systems can generally be divided into carrier systems, mechanical pumps or prodrugs, while carrier systems are predominantly macromolecular drug delivery systems, particle systems and cellular drug carriers. Polymer prodrugs belong to the macromolecule drug release system. Drugs are covalently linked to the polymer backbone and are biologically transformed to release the drug in vivo.