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流行性出血热是一种自然疫源性传染病,1935年首先发现于黑龙江沿岸,迄今已有40余年历史。建国以来,对有关病理学研究做了大量工作,病理解剖报告为数不少;但由于研究手段限于一般石蜡切片,对于病变本质和发病学仍未完全阐明。1975年以来,为深入探讨流行性出血热的发病学和病因学,我们利用光学高分辨半薄切片技术和电子显微镜对该病各期死亡病例进行了观察。发现不少特殊改变,如未曾报道过的微循环系统和平滑肌系统一些规律性损害,对于了解本病本质具有重要意义。现将观察结果报告如下。
Epidemic hemorrhagic fever is a natural foci of infectious diseases, first discovered in 1935 along the coast of Heilongjiang, so far, more than 40 years of history. Since the founding of the People’s Republic of China, a great deal of work has been done on the pathological researches, and many reports of pathological anatomy have been made. However, the research methods are limited to the general paraffin sections and the nature and pathogenesis of the lesions have not yet been fully elucidated. Since 1975, in order to further explore the epidemiology and etiology of epidemic hemorrhagic fever, we used optical high-resolution semi-thin sectioning technique and electron microscope to observe the various deaths of the disease. Found that many special changes, such as not reported some of the regularity of microcirculation and smooth muscle system damage, for understanding the nature of the disease is of great significance. The observations are reported below.