论文部分内容阅读
急性有机磷中毒并发中间综合征(IMS),发生于急性胆碱能危象之后至迟发性神经病变之前,临床常表现为迅速发展的肌无力(主要是颈肌、上肢肌、呼吸肌及颅神经支配的肌肉瘫痪),若救治不及时,可突然死于呼吸衰竭。我们在常规应用特效解毒药基础上予呼吸机治疗此类患者26例,取得较好效果。1 资料与方法1.1 病例 26例均为口服有机磷农药中毒患者。符合急性有机磷中毒并中间综合征诊断标准。其中男10例,女16例,年龄14～74岁,平均年龄41岁;久效磷中毒8例,1605中毒7例,氧化乐果中毒4例,3911中毒3例,乐果中毒2例,敌敌畏中毒1例,3911或1605两药之一亦可能为两药混合中毒1例。呼吸衰竭出现距急性胆碱能危象后时间为8～55小时,平均36小时。中间综合征发生时患者昏迷2
Acute organophosphorus poisoning complicated by intermediate syndrome (IMS), occurs after the acute cholinergic crisis to the late onset of neuropathy, the clinical manifestations of rapidly developing muscle weakness (mainly the neck muscle, upper limb muscle, respiratory muscle and Cranial nerve dominated muscle paralysis), if the treatment is not timely, can suddenly died of respiratory failure. We routinely apply special effects antidote to ventilator based on the treatment of such patients in 26 cases, and achieved good results. 1 Materials and Methods 1.1 cases were 26 cases of oral organophosphorus pesticide poisoning patients. Meet the acute organophosphate poisoning and intermediate syndrome diagnostic criteria. Including 10 males and 16 females, aged 14 to 74 years, mean age 41 years; monocrotophos poisoning in 8 cases, 1605 poisoning in 7 cases, omethoate in 4 cases, 3911 poisoning in 3 cases, dimethoate poisoning in 2 cases, 1 case of dichlorvos poisoning, 3911 or 1605 one of the two drugs may also be a mixture of two drugs poisoning. Respiratory failure appeared acute cholinergic crisis time is 8 to 55 hours, an average of 36 hours. Patients with co-occurrence of intermediate syndrome 2