甲型流感病毒的RNA聚合酶由PB1、PB2和PA三个亚基组成,在病毒的生命周期中负责行使病毒基因组的转录与复制等多方面功能.甲型流感病毒由于频繁变异,导致其对传统抗病毒药物的敏感性降低,因此开发疗效好、针对性强、毒性低的新型抗病毒药物已成为当前亟待解决的问题.由于RNA聚合酶是甲型流感病毒生命周期重要的调控蛋白,并且编码聚合酶各亚基的基因序列具有高度保守性,故成为当前抗病毒药物的重要靶点. Influenza A virus RNA polymerase consists of PB1, PB2 and PA three subunits in the life cycle of the virus responsible for the exercise of the viral genome transcription and replication and other functions. Influenza A virus due to frequent variation, leading to its Therefore, the development of a new antiviral drug with good curative effect, strong pertinence and low toxicity has become an urgent problem to be solved.As RNA polymerase is an important regulatory protein in the life cycle of the influenza A virus, and Genes encoding the subunits of the polymerase are highly conserved and therefore have become an important target of current antiviral drugs.