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目的探讨西南汉族人群中PPARγ和C-er Bb-2基因多态性与胃癌发病风险的关系。方法利用自行设计的问卷收集308对胃癌病例和对照的人口学特征和日常生活习惯,同时分析研究对象PPARγ和C-er Bb-2基因多态特征。结果 PPARγ的CC(Pro/Pro)、CG(Pro/Ala)、GG(Ala/Ala)基因型在病例组和对照组中的频率分别为90.6%、9.4%、0.0%和90.3%、9.4%、0.3%;C-er Bb-2的AA(Ile/Ile)、GA(Val/Ile)、GG(Val/Val)基因型在病例组和对照组中的频率分别为71.8%、25.6%、2.3%和75.3%、22.7%、1.9%。上述两基因多态性与全胃癌发病风险无关(PPARγPro/Pro:调整OR,1.02;95%CI:0.56~1.87;C-er Bb-2 Ile/Val:调整OR,1.08;95%CI:0.73~1.59),也与非贲门胃癌发病风险无关(PPARγPro/Pro:调整OR,0.71;95%CI:0.31~1.66;C-er Bb-2 Ile/Val:调整OR,1.24;95%CI:0.74~2.07)。未发现基因-基因联合作用和基因-环境之间的交互作用(P>0.05)。结论本研究未发现PPARγ和C-er Bb-2基因多态性与胃癌发病风险有关,且两单核苷酸多态之间无基因-基因联合作用,同时也未发现基因与环境的交互作用。
Objective To investigate the relationship between the polymorphisms of PPARγ and C-er Bb-2 gene and the risk of gastric cancer in Southwest Han population. Methods The self-designed questionnaire was used to collect 308 pairs of gastric cancer cases and controls the demographic characteristics and daily habits, and analysis of the study object PPARγ and C-er Bb-2 gene polymorphism. Results The frequency of genotypes of CC (Pro / Pro), CG (Pro / Ala) and GG (Ala / Ala) in PPARγ were 90.6%, 9.4%, 0.0% and 90.3% , 0.3% respectively. The frequencies of AA (Ile / Ile), GA (Val / Ile) and GG (Val / Val) genotypes of C-er Bb- 2.3% and 75.3%, 22.7% and 1.9% respectively. The above-mentioned two gene polymorphisms were not associated with the risk of total gastric cancer (PPARγPro / Pro: Adjusted OR, 1.02; 95% CI: 0.56-1.87; C-erbb-2lele / Val: Adjusted OR, 1.08; 95% CI: 0.73 ~ 1.59), but not with the risk of non-cardia gastric cancer (PPARγPro / Pro: adjusted OR, 0.71; 95% CI: 0.31 to 1.66; C-er Bb- ~ 2.07). No interaction between gene-gene interaction and gene-environment interaction was found (P> 0.05). Conclusions This study found no association between PPARγ and C-er Bb-2 gene polymorphisms and the risk of gastric cancer. There was no gene-gene combination between the two single nucleotide polymorphisms, and no interaction between gene and environment was found .