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目的探讨异丙酚复合0.05 mg芬太尼及0.5 mg阿托品应用对无痛人流术中宫缩的影响。方法选择要求人工流产的健康妇女300例,其中自愿要求无痛人流的200例随机分成A、B两组,每组100例,不要求无痛的100例为C组。A组应用异丙酚复合0.05 mg芬太尼及0.5 mg阿托品,B组异丙酚复合0.05mg芬太尼,C组未行镇痛。观察宫缩恢复时间、宫缩素使用情况、术中出血量,术后4 h电话随访出血情况。结果A、B两组对宫缩都有一定的抑制作用,A组宫缩恢复时间比B组长,C组始终存在宫缩。术中出血量A组比B、C两组多(P<0.01,P<0.01),B、C两组差异无统计学意义(P>0.05);术后出血例数A组较B、C组多(P<0.01,P<0.01),B组亦较C组多(P<0.01)。宫缩素使用率A组比B、C两组高(P<0.01),B组也比C组高(P<0.01)。结论异丙酚复合0.05 mg芬太尼有抑制宫缩的作用,加用0.5 mg阿托品可使宫缩恢复时间延长、出血量增多、宫缩素使用率增高。
Objective To investigate the effects of propofol combined with 0.05 mg fentanyl and 0.5 mg atropine on uterine contractions during painless abortion. METHODS: A total of 300 healthy women requiring abortion were enrolled in this study. 200 of them were randomly assigned into groups A and B, with 100 cases in each group. 100 cases were not required to be Group C. A group of propofol 0.05mg fentanyl and 0.5mg atropine, B group propofol 0.05mg fentanyl, C did not analgesic. Observe the recovery time of contractions, the use of orifices, intraoperative blood loss, telephone follow-up 4 h after surgery. Results Both groups A and B had some inhibitory effects on uterine contractions, and the duration of contractile recovery in group A was longer than that in group B, with contractions in group C at all times. The blood loss in group A was significantly higher than that in group B and C (P <0.01, P <0.01), but there was no significant difference between group B and C (P> 0.05) (P <0.01, P <0.01), and more in group B than in group C (P <0.01). Uterine contraction rate in group A was higher than that in groups B and C (P <0.01), and in group B was also higher than that in group C (P <0.01). Conclusion Propofol 0.05mg fentanyl can inhibit the role of contractions, plus 0.5mg atropine can make contractions prolonged recovery, increased bleeding, increased use of orotin.