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采用化疗、药物靶向制剂及免疫调节剂直接攻击肿瘤细胞治疗实体肿瘤的方法 ,由于受肿瘤脉管系统的屏障作用 ,难以取得满意的疗效。在肿瘤血管内皮细胞、基底膜或肿瘤基质中 ,可能存在一些潜在的肿瘤特异性靶向给药部位 ,近年来出现了导向这些靶部位的新型给药方法。这些方法通过增加肿瘤血管通透性 ,可以提高药物在肿瘤中的蓄积 ;通过抑制肿瘤血管生成并切断肿瘤供血 ,可以阻止肿瘤生长 ;通过调节肿瘤内皮细胞粘附分子的表达 ,可以诱导机体产生防卫能力 ,杀伤肿瘤细胞。
The use of chemotherapy, drug-targeted agents and immunomodulators to directly attack tumor cells to treat solid tumors is difficult to achieve satisfactory results because of the barrier function of tumor vasculature. In tumor vascular endothelial cells, basement membranes, or tumor stroma, there may be some potential tumor-specific targeted drug sites. In recent years, new drug delivery methods that target these target sites have emerged. These methods can increase the accumulation of drugs in the tumor by increasing the vascular permeability of the tumor; by inhibiting tumor angiogenesis and cutting off the tumor blood supply, tumor growth can be prevented; by regulating the expression of tumor endothelial cell adhesion molecules, the body can be induced to produce defense Ability to kill tumor cells.