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p120连环蛋白(p120 ctn)是新近发现的一种连环蛋白,目前的研究显示在多种恶性肿瘤中均发现p120 ctn有异常表达。p120 ctn已逐渐被证实与肿瘤的转移过程密切相关,但对p120 ctn在肿瘤中的作用尚有一定争议,大多数学者认为p120 ctn是肿瘤抑制因子;但也有些人认为它是肿瘤转移的促进因子。现就p120 ctn分子机制的研究进展及它在恶性肿瘤发生、发展中的可能作用进行综述。
The p120 catenin (p120 ctn) is a newly discovered catenin, and the current study shows that p120 ctn is abnormally expressed in many malignant tumors. p120 ctn has been gradually confirmed to be closely related to tumor metastasis, but the role of p120 ctn in cancer remains controversial. Most scholars think that p120 ctn is a tumor suppressor; however, some people think it is the promotion of tumor metastasis factor. Now p120 ctn molecular mechanism of research and its role in the occurrence and development of malignant tumors are reviewed.