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【目的】观察养生方破壁粉粒保肝、增强免疫和活血的药效学作用。【方法】采用四氯化碳致小鼠急性肝损伤、血清溶血素测定以及对大鼠血液流变学的影响等指标观察养生方破壁粉粒的药效学作用,并与养生方饮片进行比较。【结果】养生方破壁粉粒中、高剂量组能抑制血清谷丙转氨酶(AST)和谷草转氨酶(ALT)的升高,改善肝脏的病理学损伤;升高血清溶血素值;降低血浆粘度和全血低、中、高切粘度,从而改善血液流变学的状态。【结论】养生方破壁粉粒具有一定的保肝、改善免疫及血液流变学状态的作用。同等给药剂量比较,养生方破壁粉粒作用优于饮片。
【Objective】 To observe the pharmacodynamic effects of health-protecting powders on protecting liver, enhancing immunity and promoting blood circulation. 【Methods】 The effects of carbon tetrachloride-induced acute hepatic injury, serum hemolysin determination, and hemorheology on rats were used to observe the pharmacodynamic effects of the decoction powder on the health side, and the results were compared with those of health prescriptions. Compare. 【Results】 The high-dose group can inhibit the elevation of serum glutamic-pyruvic transaminase (AST) and aspartate aminotransferase (ALT), improve the pathological damage of the liver, increase serum hemolysin value, and reduce plasma viscosity. And low, medium and high cut viscosity of whole blood to improve the state of blood rheology. 【Conclusion】 The antibiotics have a certain degree of hepatoprotection, improve immunity and hemorheology. Compared with the same dose, the function of the broken side of the health side was superior to the decoction.