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在新型的季鏻盐型三相相转移催化剂作用下,使用邻苯二甲酰亚胺为亲核取代试剂,与溴代正丁烷发生N-烷基化取代反应,生成N-正丁基邻苯二甲酰亚胺.考察了三种间隔臂不同的季鏻盐型三相相转移催化剂(QP-CPS)的催化效果,结果表明,这三种相转移催化剂对N-正丁基邻苯二甲酰亚胺的合成有明显的催化作用,且间隔臂越长的QP-CB-CPS催化活性越强,当催化剂用量为4 mmol,反应温度为90℃,反应12 h时溴代正丁烷的转化率可达到87%.另外,以催化剂QP-CA-CPS为例,考察了各种因素对三相相转移催化反应的影响规律.结果表明,有机溶剂的极性越强,催化剂的活性越高,且有机相与水相的体积比例以及搅拌速度均对相转移催化效果有较大的影响
Under the action of a novel quaternary phosphonium salt type three-phase phase transfer catalyst, phthalimide is used as a nucleophilic substitution reagent to undergo N-alkylation substitution reaction with n-butyl bromide to generate N-n-butyl o-benzene Dicarboximide.The catalytic effect of quaternary phosphonium salt-type three-phase phase transfer catalyst (QP-CPS) with different interval arms was investigated. The results showed that the three phase transfer catalysts exhibited good performance for N-n-butylphthalyl The synthesis of imine has obvious catalysis, and the longer the interval arm, the stronger the catalytic activity of QP-CB-CPS. When the amount of catalyst is 4 mmol, the reaction temperature is 90 ℃, the conversion of n-butane bromide The rate can reach 87% .In addition, taking the catalyst QP-CA-CPS as an example, the effects of various factors on the three-phase phase transfer catalysis were investigated.The results showed that the stronger the polarity of the organic solvent, the higher the activity of the catalyst , And the volume ratio of the organic phase to the aqueous phase as well as the stirring speed have a greater impact on the phase transfer catalysis