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为了探讨小气道病变与肺弹性回缩力变化之间的关系,作者对54个尸解肺标本进行研究,包括15个无肺气肿的肺标本及39个有不同程度肺气肿的肺标本。结果发现肺气肿组小气道病理总分、纤维化及色素沉积计分均高于无肺气肿组。如将两组资料合并处理,发现小气道病理总分与小气道平均内口径(IB)显著相关(r=-0.309,P<0.03),与内径≤0.4mm的小气道数/受检的内径≤2.0mm气道总数的百分率显著相关(r=-0.440,P<0.001);小气道病理总分与肺气肿程度显著相关(r=0.583,P<0.001);若将肺弹性回缩力表示为90%总肺活量(TLC)位时正常预计值的%,则发现小气道病理总分与其呈负相
In order to investigate the relationship between small airway lesions and changes in pulmonary elastic contractility, the authors studied 54 autopsy lung specimens, including 15 lung specimens without emphysema and 39 lung specimens with varying degrees of emphysema . The results showed that small airway pathological score, fibrosis and pigmentation scores in emphysema group were higher than those without emphysema group. If the two sets of data were combined, it was found that the total small airway pathology score was significantly correlated with the mean internal airway diameter (IB) (r = -0.309, P <0.03) and the small airway diameter≤0.4 mm / (R = -0.440, P <0.001). The total pathological score of small airway was significantly correlated with the degree of emphysema (r = 0.583, P <0.001). If the pulmonary elastic retraction force Expressed as a% of the normal expected value at the 90% total vital capacity (TLC) position, the total small airway pathology score was found to be negative