脑卒中、血栓形成和动脉粥样硬化的动物模型流行病学和临床研究显示,某些环境因素例如盐的摄入或紧张,对人类高血压的发病具有重要影响。自发发生高血压、脑卒中和动脉粥样硬化的动物模型,能使我们不仅可以用实验方法研究心血管疾病的发病机理及其治疗,而且还可研究发生这些疾病有关的环境因素及其预防方法。采用选择性繁殖的方法,可从自发性高血压大鼠(SHR)中培 Animal Models of Stroke, Thrombosis, and Atherosclerosis Epidemiological and clinical studies have shown that certain environmental factors, such as salt intake or stress, have a significant impact on the incidence of human hypertension. Animal models of spontaneous hypertension, stroke, and atherosclerosis enable us not only to experimentally study the pathogenesis of cardiovascular disease and its treatment, but also to investigate the environmental factors associated with these diseases and their prevention . Selective breeding methods can be used in spontaneously hypertensive rats (SHR)