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目的探讨甲泼尼龙联合大环内酯类抗生素治疗小儿支原体肺炎的临床疗效。方法选取上高县人民医院2012—2014年收治的小儿支原体肺炎患儿100例,采用随机数字表法分为对照组与试验组,各50例。对照组给予常规对症处理+静脉滴注乳糖酸红霉素及口服阿奇霉素治疗,试验组在对照组基础上加用甲泼尼龙治疗。比较两组患儿退热时间、咳嗽缓解时间、肺部啰音消失时间、治愈时间及住院时间,观察两组患者临床疗效及药物不良反应发生情况。结果试验组患儿退热时间、咳嗽缓解时间、肺部啰音消失时间、治愈时间及住院时间均短于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论甲泼尼龙联合大环内酯类抗生素治疗小儿支原体肺炎的临床疗效确切,可有效改善小儿支原体肺炎的临床预后,缩短病程。
Objective To investigate the clinical efficacy of methylprednisolone and macrolide antibiotics in the treatment of Mycoplasma pneumonia in children. Methods 100 cases of pediatric children with mycoplasma pneumonia admitted from 2012 to 2014 in Shanggao People’s Hospital were randomly divided into control group and trial group with 50 cases in each group. Control group was given conventional symptomatic treatment + intravenous infusion of erythromycin lactobionate and oral azithromycin treatment group in the control group based on the addition of methylprednisolone treatment. The antipyretic time, cough relief time, pulmonary rales disappearance time, cure time and hospital stay were compared between the two groups. The clinical efficacy and adverse drug reactions in both groups were observed. Results The total effective rate of fever relief time, cough relief time, disappearance of pulmonary rales, healing time and hospital stay in the experimental group were shorter than those in the control group. The difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Methylprednisolone combined with macrolide antibiotics in children with mycoplasma pneumonia clinical curative effect is exact, can effectively improve the clinical prognosis of children with mycoplasma pneumonia, shorten the course of the disease.