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自身免疫性胆管炎是一种有原发性胆汁性肝硬化(PBC)的临床和病理特征,但其抗线粒体抗体(AMA)阴性而抗核抗体(ANA)阳性。为明确自身免疫性胆管炎的特征及其与PBC是否真正不同,作者复习1972年至1992年根据肝活检确诊的且有AMA和ANA检测资料的200例PBC病人。根据AMA和ANA阳性情况,将病人分为四组,对临床、病理和实验室资料进行统计学分析。 结果:200例病人分为AMA和ANA均阴性(24例)组、AMA阴性和ANA阳性(自身免疫性胆管炎,40例)组、AMA阳性和ANA阴性(典型PBC,62例)组及两者均阳性(74例)组。
Autoimmune cholangitis is a clinical and pathological feature of primary biliary cirrhosis (PBC), but it is anti-mitochondrial antibody (AMA) negative and anti-nuclear antibody (ANA) positive. To clarify the characteristics of autoimmune cholangitis and whether it is truly different from PBC, the authors reviewed 200 PBC patients diagnosed with liver biopsy and AMA and ANA test data from 1972 to 1992. According to the AMA and ANA positive cases, the patients were divided into four groups, and the clinical, pathological and laboratory data were statistically analyzed. Results: The 200 patients were divided into AMA group and ANA group (24 cases), AMA negative group and ANA group (40 cases), AMA positive group and ANA negative group (62 cases) All were positive (74 cases) group.