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Objectives: Document obesity-extreme obesity in most 20-24, 25-29, and 32-41 years old women with PCOS as a stimulus for physicians to consider the diagnosis of PCOS, an underlying reversible endocrinopathy. Study design: In matched age groups 20-24, 25-29, and 32-41 years, we compared BMI in 84, 129, and 188 Caucasian women with PCOS versus 956, 815, and 815 women in NHANES I (general population), and 25, 36, and 45 non-pregnant women (community obstetrics practice). Results: At ages 20-24, 25-29, and 32-41 years, mean ±SD BMIs in women with PCOS (35.3 ±7.7, 36.0 ±9.4, 36.7 ±8.2) were much greater than NHANES I (22.8 ±4.6, 23.3 ±5.0, 24.5 ±5.6; p < .0001), and community (26.1 ±6.8, 26.9 ±6.6, 25.2 ±5.2; p < .0001). Classifying BMI < 25 (normal), ≥25-30 (overweight), ≥30-40 (obese), ≥40 (extremely obese), at ages 20-24, 25-29, and 32-41 years: 76, 73, and 78%of PCOS women were obese-extremely obese, versus 7, 11, and 14%of NHANES I, and 20, 28, and 15%of community women. At ages 20-24, 25-29, and 32-41 years, only 10, 12, and 7%PCOS women had BMIs < 25, versus 78, 74, and 66%NHANES I, and 48, 47, and 58%of community women. Conclusions: Obesity-extreme obesity in women, manifest by ages 20-24 years, continuing through 32-41 years, shouldalert physicians to the likelihood of PCOS, an underlying, heritable, potentially reversible, insulin resistant endocrinopathy that promotes obesity.
Objectives: Document obesity-extreme obesity in most 20-24, 25-29, and 32-41 years old women with PCOS as a stimulus for physicians to consider the diagnosis of PCOS, an underlying reversible endocrinopathy. Study design: In matched age groups 20-24, 25-29, and 32-41 years, we compared BMI in 84, 129, and 188 Caucasian women with PCOS versus 956, 815, and 815 women in NHANES I (general population), and 25, 36, and 45 non-pregnant women (community obstetrics practice). Results: At ages 20-24, 25-29, and 32-41 years, mean ± SD BMIs in women with PCOS (35.3 ± 7.7, 36.0 ± 9.4, 36.7 ± 8.2) were much greater than NHANES I (22.8 ± 4.6, 23.3 ± 5.0, 24.5 ± 5.6; p <.0001), and community (26.1 ± 6.8, 26.9 ± 6.6, 25.2 ± 5.2; p <.0001) (normal), ≥25-30 (overweight), ≥30-40 (obese), ≥40 (extremely obese), ages 20-24, 25-29, and 32-41 years: 76, 73, and 78% of PCOS women were obese-extremely obese, versus 7, 11, and 14% of NHANES I, and 20, 28, and 15% of community women . At ages 20-24, 25-29, and 32-41 years, only 10, 12, and 7% of PCOS women had BMIs <25, versus 78, 74, and 66% of NHANES I, and 48, 47, and 58 % of community women. Conclusions: Obesity-extreme obesity in women, manifest by ages 20-24 years, continuing through 32-41 years, shouldalert physicians to the likelihood of PCOS, an underlying, heritable, potentially reversible, insulin resistant endocrinopathy that promotes obesity.