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目的 :探讨慢性阻塞性肺病 (chronic obstructive pulmonary disease,COPD)日间动脉血氧分压 (Pa O2 )、动脉血二氧化碳分压 (Pa CO2 )对夜间血氧的影响。方法 :监测 30例 COPD患者和 10例正常对照的夜间血氧水平 ,按 Pa O2 、Pa CO2 分组比较。结果 :(1) Pa O2 >8k Pa时 ,睡眠时平均动脉血氧饱和度 (MSa O2 )与日间动脉血氧饱和度(Sa O2 ) ,一秒率 (FEV1 % )、Pa CO2 均相关 (P均 <0 .0 5 ) ;Pa O2 ≤ 8k Pa时 ,MSa O2 仅与 Sa O2 相关 (P <0 .0 5 ) ;(2 ) Pa O2 >8k Pa时 ,日间 Pa CO2 >6 k Pa者睡眠时最低动脉血氧饱和度 (Min Sa O2 )与日间 Pa CO2 相关 (P <0 .0 5 ) ,日间 Pa CO2 ≤ 6 k Pa者 Min Sa O2 与日间 Pa O2 相关 (P <0 .0 5 )。结论 :COPD患者日间 Pa O2 决定睡眠时血氧平均水平 ,Pa CO2 则与睡眠时血氧最低水平密切相关
Objective: To investigate the effects of PaO2 and PaCO2 on nocturnal oxygenation in patients with chronic obstructive pulmonary disease (COPD). Methods: Nocturnal oxygen levels in 30 patients with COPD and 10 normal controls were monitored. PaO2 and Pa CO2 groups were compared. Results: (1) Mean arterial oxygen saturation (MSa O2) during sleep was correlated with daytime arterial oxygen saturation (Sa O2), one second rate (FEV1%) and Pa CO2 at Pa O2> 8kPa P <0. 05). When Pa O2 ≤ 8k Pa, MSa O2 was only related to Sa O2 (P <0.05); (2) Pa Pa> 6k Pa Min Sa O2 during sleep correlated with daytime PaCO2 (P <0.05), daytime Pa CO2 ≤6k Pa with Min Sa O2 correlated with daytime PaO2 (P < 0 .0 5). CONCLUSIONS: Daytime Pa O2 decides the mean level of blood oxygen during sleep, and Pa CO2 is closely related to the lowest level of blood oxygen during sleep