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目的回顾性分析局限期小细胞肺癌(LSCLC)患者的放化疗效果及生存状况。方法选取2012年1月至2013年12月在山东省滕州市中心人民医院肿瘤科接受放化疗联合治疗的60例LSCLC患者为研究对象,随访24个月,观察疗效和预后影响因素。回顾性分析60例LSCLC患者的放化疗临床资料,采用kapian-meier法对各项临床因素进行单因素分析,Cox回归模型进行多因素分析。结果患者的总有效率为93.3%。骨髓抑制、胃肠道不适和放射性食管炎是患者放化疗后的主要不良反应。其中≥3级骨髓抑制发生率为61.7%,≥3级消化道不适发生率为70.0%,≥3级放射性食管炎发生率为40.0%。吸烟史为影响患者生存的显著危险因素(P=0.02)。化疗周期、体重和近期疗效为独立预后影响因素。结论 LSCLC患者采用放化疗综合治疗疗效显著,吸烟史为影响患者生存的显著危险因素,化疗周期、体重和近期疗效为独立预后影响因素。
Objective To retrospectively analyze the effect of radiotherapy and chemotherapy and its survival in patients with minimally delayed small cell lung cancer (LSCLC). Methods From January 2012 to December 2013, 60 patients with LSCLC treated with radiochemotherapy combined with radiotherapy and chemotherapy in Department of Oncology, People's Hospital of Tengzhou City, Shandong Province were selected as the study subjects and followed up for 24 months to observe the effect and prognostic factors. The clinical data of chemoradiotherapy in 60 patients with LSCLC were retrospectively analyzed. Univariate analysis of clinical factors and multivariate analysis were performed by Cox regression model using kapian-meier method. Results The total effective rate of patients was 93.3%. Myelosuppression, gastrointestinal upset, and radiation esophagitis are the major side effects of chemoradiation in patients. The grade 3 myelosuppression was 61.7%, the grade 3 digestive discomfort was 70.0%, the grade 3 esophageal esophagitis was 40.0%. Smoking history was a significant risk factor affecting patient survival (P = 0.02). Chemotherapy cycle, body weight and short-term efficacy as independent prognostic factors. Conclusion The comprehensive treatment of LSCLC with radiotherapy and chemotherapy is effective. Smoking history is a significant risk factor for survival. Chemotherapy cycle, body weight and short-term efficacy are the independent prognostic factors.