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阿司匹林作为解热镇痛药已有近百年的历史,至今仍在选用。自发现其有抗凝作用后,临床用于预防心肌梗塞,但应用多大剂量最为合适各家论点不一。基于阿司匹林可抑制血栓素A_2(TXA_2)的合成,故常用来预防心肌梗塞。但它又能抑制前列腺环素(PGI_2)的合成,只不过两者对其敏感性不同而已。因此,阿司匹林的理想剂量应能抑制TXA_2的合成,而不抑制或很少抑制PGI_2的合成。尽管研究者们都证明阿司匹林有显著的抗血小板聚积作用,但目前所用剂量极不统一,最小为20毫克/日,最大为1500
Aspirin as antipyretic analgesics for nearly a hundred years of history, is still in use. Since the discovery of its anticoagulant effect, the clinical use for the prevention of myocardial infarction, but the most appropriate dose of the most appropriate arguments vary. Aspirin can inhibit thromboxane A_2 (TXA_2) synthesis, it is often used to prevent myocardial infarction. However, it inhibits the synthesis of prostacyclin (PGI_2), but the sensitivity of both is different. Therefore, the ideal dose of aspirin should be able to inhibit the synthesis of TXA_2 without inhibiting or rarely inhibiting the synthesis of PGI_2. Although researchers have shown that aspirin has a significant anti-platelet aggregation effect, the dose currently used is extremely uniform, with a minimum of 20 mg / day and a maximum of 1500