论文部分内容阅读
目的:探讨OSAHS患者外周血肝细胞生长因子(HGF)的检测及其意义。方法:选择96例OSAHS患者作为OSAHS组,根据鼾症程度分为轻、中、重3组,每组32例;以体检科35例正常人作为对照组。采用ELISA法测定血清HGF浓度,32例重度OSAHS患者综合治疗3个月,复测HGF浓度,分析血清HGF与睡眠呼吸事件各指标的相关性。结果:外周血HGF浓度随OSAHS患者病情严重程度呈递增趋势,对照组与轻、中、重组血清HGF水平分别为(487.75±46.74)pg/ml、(519.44±50.77)pg/ml、(753.52±58.91)pg/ml、(829.49±61.74)pg/ml,组间相互比较均差异有统计学意义(F=117.733,P<0.01);OSAHS患者外周血HGF水平和年龄、性别、BMI无关(P>0.05),与AHI呈正相关(P<0.01),与LSaO2呈负相关(P<0.01);32例重度OSAHS患者综合治疗后血清HGF水平及AHI较治疗前下降,LSaO2上升,差异有统计学意义(P<0.01)。结论:OSAHS患者体内HGF水平升高,与其病情严重程度呈正相关,测定外周血HGF水平对判断OSAHS病情严重程度和血管内皮功能损害程度、评估患心血管疾病的风险性具有一定的临床意义。
Objective: To investigate the detection of hepatocyte growth factor (HGF) in peripheral blood of patients with OSAHS and its significance. Methods: Ninety-six patients with OSAHS were selected as OSAHS group. According to the degree of snoring, the patients were divided into three groups: mild, moderate and severe, 32 cases in each group. 35 normal subjects were selected as the control group. Serum HGF concentration was measured by ELISA. 32 patients with severe OSAHS were treated with combined therapy for 3 months. HGF concentration was measured and the correlation between serum HGF and sleep apnea events was analyzed. Results: The HGF concentration in peripheral blood increased with the severity of OSAHS. The levels of serum HGF in the control group and those in the mild, moderate and severe groups were (487.75 ± 46.74) pg / ml, (519.44 ± 50.77) pg / ml and (753.52 ± 58.91) pg / ml and (829.49 ± 61.74) pg / ml respectively. There was significant difference between the two groups (F = 117.733, P <0.01). The level of HGF in peripheral blood of OSAHS patients was not related to age, sex and BMI (P <0.01), but negatively correlated with LSaO2 (P <0.01). The serum HGF levels and AHI in 32 OSAHS patients after treatment were significantly lower than those before treatment, and the difference was statistically significant Significance (P <0.01). Conclusions: The level of HGF in OSAHS patients is positively correlated with the severity of OSAHS. Determining the level of HGF in peripheral blood is of clinical significance for judging the severity of OSAHS and the degree of vascular endothelial dysfunction and assessing the risk of cardiovascular diseases.