论文部分内容阅读
用亚急性吸入油烟大鼠中毒模型，观察了睾丸曲细精管各级生精细胞、附睾上皮超微结构改变。变化特点是，精原细胞核固缩、胞质髓鞘样结构；精母细胞、精子细胞、支持细胞核内染色质凝集成块，核膜间隙增宽、凹陷、缺损，线粒体嵴消失、肿胀，光滑内质网肿胀，溶酶体增加；精母细胞核内有包涵物，精子细胞有核溶解，光滑内质网极度肿胀呈空泡状、细胞坏死征象；曲细精管基底膜排列紊乱、扭曲；附睾上皮纤毛紊乱、变短；精子头部畸形。结果提示，油烟对雄性动物性腺具有毒性作用；各级生精细胞的细胞核、线粒体可能是其主要靶位。
Subacute inhalation of smoke poisoning rat model, observe the seminiferous tubules at all levels of spermatogenic cells, epididymal epithelial ultrastructure changes. Changes are characterized by spermatogonial nuclear condensation, cytoplasmic myelin-like structure; spermatocytes, sperm cells, support the nucleus chromatin agglutination block, the nuclear membrane gap widened, depression, defect, disappearance of mitochondrial cristae, swelling, smooth Endoplasmic reticulum swelling, increased lysosomes; inclusions in the nucleus of spermatocytes, sperm cells nucleolus dissolved, smooth endoplasmic reticulum extremely swollen vacuoles, signs of cell necrosis; seminiferous tubules basement membrane disordered, distorted; Epididymal ciliated disorders, shorter; sperm head deformity. The results suggest that the fume has a toxic effect on male gonads; nuclei and mitochondria of spermatogenic cells at all levels may be the main targets.