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采用重组干扰素。α-2b(IFNα-2b)治疗活动性丙型肝炎患者2例,并用巢式多聚酶链反应(PCR)检测患者治疗前后HCV-RNA的血清学变化作为疗效评判标准。结果显示;2例患者血清HCV-RNA的治疗后2～4周即转阴,在三个月的治疗过程中,连续观察呈持续阴性,且伴抗HCV阴转,血清ALT恢复正常水平。研究结果提示IFNα-2b是目前治疗丙肝较为有效的药物之一。
Using recombinant interferon. α-2b (IFNα-2b) in patients with active hepatitis C were detected in 2 patients. Serum changes of HCV-RNA before and after treatment were detected by nested polymerase chain reaction (PCR). The results showed that HCV-RNA in 2 patients turned negative 2 to 4 weeks after treatment, and continued to be negative in the course of three months treatment, accompanied by anti HCV negative conversion and serum ALT returned to normal levels. The results suggest that IFNα-2b is currently one of the more effective drugs for the treatment of hepatitis C.