论文部分内容阅读
瘦素是由肥胖基因编码的一种多肽激素 ,具有调节能量代谢和抑制食欲的作用 ,其调节作用由瘦素受体所介导。瘦素受体属于 I类细胞因子受体家族。 JAK- STAT途径是瘦素信号转导的主要途径。瘦素与胰岛素的信号转导通路之间存在“cross talk”。
Leptin is a polypeptide hormone encoded by obesity gene. It has the function of regulating energy metabolism and appetite suppression, and its regulation is mediated by leptin receptor. Leptin receptors belong to the class I cytokine receptor family. The JAK-STAT pathway is the main pathway for leptin signaling. There is a “cross talk” between leptin and insulin signaling pathways.