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bifonazole 是取代咪唑类抗真菌药,在体外它对表皮真菌、霉菌、酵母、二形真菌和一些G~+菌有广谱活性。对照和非对照的临床试验明确证实,每天应用一次1% bifonazole 的各种制剂(油膏、凝胶、溶液和粉末)对表皮真菌感染如皮肤真菌病、皮念珠菌病和花斑糠疹的疗效和安全性。在对照试验中,bifona-zole 明显地优于安慰剂,至少和其它咪唑类抗真菌药包括克霉唑、益康唑、咪康唑、奥昔康唑和硫康唑同样有效。对其它表皮和指甲感染/皮肤病的初步试验,提出bifonazole 可能用于治疗指甲真菌病
Bifonazole is a substituted imidazole antifungal agent that has broad spectrum activity against epidermal fungi, molds, yeasts, pleomorphs and some G ~ + bacteria in vitro. Controlled and uncontrolled clinical trials have clearly demonstrated that various formulations (ointments, gels, solutions and powders) of 1% bifonazole are administered daily to epidermal fungal infections such as dermatophytosis, candidiasis and pityriasis versicolor Efficacy and safety. In controlled trials, bifona-zole was significantly better than placebo, at least as effective as other imidazole antifungals including clotrimazole, econazole, miconazole, oxiconazole and sulconazole. Preliminary tests on other epidermal and nails infections / dermatoses suggest that bifonazole may be used to treat nail fungal diseases