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结直肠癌是常见的消化道恶性肿瘤之一,其发病率地区差异较大,与世界上较发达国家相比,我国属于低发病区域,但随着生活方式的改变,呈现发病率日渐升高趋势。结肠癌早期起病隐匿,且病情发展较慢,出现明显症状而就诊的患者多数已处于中晚期。结直肠癌的预后相对较好,统计显示,根治术后五年生存率可达50%以上,其中,早期诊断并采取手术根除的患者五年生存率可高达80%以上,而晚期患者术后五年生存率仅有30%左右。因此早期诊断及早期治疗对结肠癌患者的预后尤为重要。文章就组织蛋白酶D、MMP-9、CD44V6与肿瘤特别是大肠癌转移之间的关系作一综述。
Colorectal cancer is one of the most common malignant tumors of the digestive tract, and its incidence varies greatly from place to place. Compared with the more developed countries in the world, colorectal cancer is a low-incidence area. However, with the change of lifestyle, the incidence of colorectal cancer is on the rise trend. Early onset of colon occult occult, and the slow progression of the disease, the apparent symptoms of the majority of patients already in the mid-late. The prognosis of colorectal cancer is relatively good, statistics show that five-year survival rate after radical operation up to 50%, of which early diagnosis and radical eradication of patients with five-year survival rate can be as high as 80% or more, while patients with advanced postoperative Five-year survival rate of only about 30%. Therefore, early diagnosis and early treatment of colon cancer prognosis is particularly important. The article reviews the relationship between cathepsin D, MMP-9, CD44V6 and tumor metastasis, especially colorectal cancer.