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棒酸(CAV)为β-内酰胺酶抑制剂,可与β-内酸胺酶结合成不可逆解的复合物,保护AMX免受该酶破坏,使已耐药菌株恢复其敏感性.且两者主要药动学参数相近,基于此,国内外相继出现多种CAV/AMX的复方制剂,如安灭菌(注射剂)、安克片、安奇颗粒剂及混悬剂等.笔者就其适应症和临床应用剂量问题,谈点看法,供参考.1 适应症问题在一些宣传品中,把各种致病菌引起的疾病都包括在内,上至呼吸道,下至泌尿系统,外至皮肤,内至骨髓所有的炎症均可使用.加上“强效抑酶”、“以寡敌众”等夸张用语.似乎凡感染性疾病“药到病除”.从CAV/AMX与AMX抗菌活性比较(见表1)中可知,某些提法是不够严肃的,可能误导.
Clavulanic acid (CAV) is a β-lactamase inhibitor that binds to β-lactamase to form an irreversible complex that protects AMX from damage by the enzyme and restores the drug-resistant strain to its sensitivity. The main pharmacokinetic parameters are similar, based on this, a variety of CAV / AMX compound preparations have emerged at home and abroad, such as sterilization (injection), Anke tablets, An Qi granules and suspensions, etc. The author on its adaptation Symptoms and clinical application of dose problems, talk about the point of view, for reference.1 indicationsIn some promotional materials, a variety of diseases caused by pathogenic bacteria are included, up to the respiratory tract, down to the urinary system, outside to the skin , All the inflammation within the bone marrow can be used.And with the “strong inhibitory enzyme”, “the enemy with the public” and other exaggerated terms .It seems that any infectious disease “medicine to sick.” From CAV / AMX and AMX antibacterial activity A comparison (see Table 1) shows that some references are not serious enough and may be misleading.