论文部分内容阅读
目的研究山莨菪碱对支气管哮喘的疗效及对血清中白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)及白细胞介素-12(IL-12)表达的影响,以探讨其临床意义。方法选取136例支气管哮喘患者,按患者入院顺序分为观察组(68例)与对照组(68例),观察组在常规治疗基础上加用山莨菪碱治疗,对照组应用常规治疗。于治疗前、治疗后观察血清中IL-1β、IL-8及IL-12的变化,比较其差异。结果观察组的疗效明显优于对照组。观察组与对照组在治疗后血清中IL-1β、IL-8及IL-12的表达均较治疗前明显降低,但观察组治疗后的下降值明显高于对照组。结论支气管哮喘患者在常规治疗基础上加用山莨菪碱治疗,效果明显,且能对血清中IL-1β、IL-8及IL-12有重要的调节作用。
Objective To study the effects of anisodamine on bronchial asthma and its effects on the expression of interleukin-1β (IL-1β), interleukin-8 (IL-8) and interleukin-12 (IL- To explore its clinical significance. Methods A total of 136 patients with bronchial asthma were selected and divided into observation group (68 cases) and control group (68 cases) according to admission order. The observation group was treated with anisodamine on the basis of routine treatment and the control group was treated by conventional therapy. Before treatment and after treatment, the changes of IL-1β, IL-8 and IL-12 in serum were observed and compared. Results The observation group was significantly better than the control group. After treatment, the levels of IL-1β, IL-8 and IL-12 in the observation group and the control group were significantly lower than those before treatment, but the decrease in the observation group was significantly higher than that in the control group. Conclusions Bronchial asthma patients treated with Anisodamine on the basis of routine treatment have obvious effect and can play an important regulatory role on IL-1β, IL-8 and IL-12 in serum.