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目的了解类风湿关节炎外周血中Bcl- 2检测的意义。方法 用流式细胞仪检测 2 2例类风湿关节炎患者 (RA)外周血和培养后单个核细胞Bcl- 2蛋白的表达 ,并与 2 0例正常对照比较。结果 RA组外周血和培养后单个核细胞的Bcl- 2蛋白表达明显高于对照组 (P <0 0 5 ) ,但未观察到与Stoke指数的相关性。结论 RA患者存在细胞凋亡调控异常 ,这可能在RA发病机制中起一定作用。
Objective To understand the significance of Bcl-2 in peripheral blood of patients with rheumatoid arthritis. Methods Flow cytometry was used to detect the expression of Bcl-2 protein in peripheral blood of 22 patients with rheumatoid arthritis (RA) and cultured mononuclear cells, and compared with 20 normal controls. Results The expression of Bcl-2 in peripheral blood and mononuclear cells in RA group was significantly higher than that in control group (P <0.05), but no correlation with Stoke index was observed. Conclusion There is abnormal regulation of apoptosis in RA patients, which may play a role in the pathogenesis of RA.