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目的探讨中国汉族人群argonaute1rs636832A>G基因多态性对食管癌淋巴结转移危险因素的影响。方法采用以医院为基础的病例-病例研究方法,基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)技术分析380例食管癌argonaute1rs636832A>G基因多态性,计算各种基因型的食管癌淋巴结转移风险及其95%可信区间。结果食管癌淋巴结转移组和无转移组argonaute1rs636832A>G多态性位点频率无明显差异。Logistic回归显示,与携带argonaute1rs636832AA基因型的个体相比较,携带argonaute1rs636832GG等位基因型与食管癌淋巴结转移风险无明显相关(OR=0.69,95%CI=0.25-1.92)。结论 Argonaute1rs636832A>G基因多态性可能与食管癌淋巴结转移无明显相关。
Objective To investigate the effect of argonaute1rs636832A>G polymorphism on risk factors of lymph node metastasis of esophageal cancer in Chinese Han population. Methods A hospital-based case-case study was performed. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to analyze the polymorphism of argonaute1rs636832A>G gene in 380 cases of esophageal cancer. The genotypes of esophageal cancer lymph nodes were calculated. Transfer risk and its 95% confidence interval. Results There was no significant difference in the frequency of the polymorphism of argonaute1rs636832A>G between esophageal cancer with lymph node metastasis and without metastasis. Logistic regression showed that carrying the argonaute1rs636832GG allele did not significantly correlate with the risk of lymph node metastasis in esophageal cancer compared with individuals carrying the argonaute1rs636832AA genotype (OR=0.69, 95%CI=0.25-1.92). Conclusion Argonaute1rs636832A>G polymorphism may not be significantly associated with lymph node metastasis in esophageal cancer.