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目的:观察布拉氏酵母菌散加复方碳酸钙泡腾颗粒防治婴幼儿肺炎相关性腹泻的效果与安全性。方法:将因支气管肺炎需使用抗生素的180例婴幼儿分为两组各90例。预防组给予抗生素和对症治疗,同时服用布拉氏酵母菌散加复方碳酸钙泡腾颗粒;对照组出现腹泻后服用布拉氏酵母菌散加用双八面体蒙脱石散。比较两组腹泻患儿所占比例、腹泻次数、腹泻持续时间和疗效。结果:防治组腹泻发生率(58.2%)显著低于对照组(56.9%,P<0.05),预防组患儿腹泻持续(4.1±1.0)d,对照组(4.8±0.8)d,差异无有统计学意义(P>0.05)。两组出现腹泻后第3,5天便次比较,预防组显著少于对照组(P<0.01)。结论:布拉氏酵母菌散可能有利于减少婴幼儿肺炎相关性腹泻,早期应用可能有利于缩短腹泻持续时间和腹泻次数,利于患儿康复。
OBJECTIVE: To observe the efficacy and safety of the combination of Saccharomyces cerevisiae with compound calcium carbonate effervescent granules in prevention and treatment of pneumonia-associated diarrhea in infants and children. Methods: One hundred and eighty infants who needed antibiotics for bronchopneumonia were divided into two groups of 90 cases each. Prevention group was given antibiotics and symptomatic treatment, while taking Saccharomyces cerevisiae powder plus compound calcium carbonate effervescent granules; control group after taking diarrhea, take Brachyspira added with double octahedral montmorillonite powder. The proportion of children with diarrhea, the number of diarrhea, the duration of diarrhea and the curative effect were compared between the two groups. Results: The incidence of diarrhea in control group (58.2%) was significantly lower than that in control group (56.9%, P <0.05). The incidence of diarrhea in prevention group was (4.1 ± 1.0) d and that in control group (4.8 ± 0.8) Statistical significance (P> 0.05). The two groups were compared on the 3rd and 5th day after diarrhea, the prevention group was significantly less than the control group (P <0.01). CONCLUSIONS: B. Cerevisiae powder may be helpful to reduce pneumonia-related diarrhea in infants and young children. Early application may be beneficial to shorten the duration of diarrhea and the number of diarrhea, which will benefit the recovery of children.