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[目的]监测2009—2010年上海市长宁区甲型H_1N_1流行性感冒(甲流)疫苗接种的安全性。[方法]通过上海市预防接种异常反应(adverse events following immunization,AEFI)监测系统,以被动监测方式收集长宁区甲流疫苗接种人群截至2010年12月31日的AEFI个案信息,同时通过问卷和电话随访的主动监测方式收集其中4所中小学校师生的AEFI个案信息开展评价。[结果]上海市长宁区共接种甲流疫苗86934人,甲流疫苗AEFI被动监测报告发生率为53.04/10万,其中异常反应报告发生率为8.25/10万;4所中小学校接种甲流疫苗2092人,甲流疫苗AEFI主动监测报告发生率为8221.80/10万,主动监测的AEFI报告发生率明显高于被动监测。甲流疫苗AEFI报告对象的临床表现以发热、局部反应和主诉不适为主,异常反应以过敏性反应为主,无严重不良反应发生。[结论]甲流疫苗AEFI被动监测的漏报情况主要发生在一般反应,甲流疫苗的安全性与季节性流行性感冒疫苗相当。
[Objective] To monitor the safety of H1N1 influenza A (H1N1) vaccination in Changning District of Shanghai from 2009 to 2010. [Methods] AEFI monitoring system was used in Shanghai to collect information on AEFI cases of Influenza A vaccination in Changning District as of December 31, 2010 by passive monitoring. The questionnaire and telephone number Follow-up initiative to monitor the collection of four primary and secondary school teachers and students AEFI case information for evaluation. [Results] A total of 86,934 Influenza A vaccines were vaccinated in Changning District of Shanghai. The incidence of AEFI passive surveillance of Influenza A was 53.04 / 100 000, of which 8.25 / 100,000 were reported. Four primary and secondary schools inoculated with Influenza A 2092 people, AEFI influenza AEFI initiative monitoring report was 8221.80 / 100 000, the incidence of active monitoring of AEFI was significantly higher than the passive monitoring. AEFI report the clinical manifestations of the object to fever, local reactions and complaints of the main complaints, anaphylaxis with allergic reactions, no serious adverse reactions. [Conclusion] The omission report of AEFI passive monitoring of H1N1 vaccine mainly occurred in the general reaction. The safety of H1N1 vaccine was similar to that of seasonal influenza vaccine.