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C蛋白为人血浆中一种维生素K依赖蛋白,由肝脏合成,活化的C蛋白具有抗血栓形成的作用,此作用是由于V因子和Ⅶ因子的灭活及循环纤溶酶原活化素水平的提高而引起的。后天的C蛋白缺乏,在慢性肝病,成人呼吸窘迫综合症、弥慢性血管内凝血、外科术后等已有报道,C蛋白在调节凝固和纤溶之间的平衡方面似乎起着重要作用。作者发现,血透析病人的C蛋白水平经测定,提示C蛋白的活性降低与渐进性的肾功能衰竭之间有相关性,在肾病和尿毒症时所见到的血栓形成倾向中,C蛋白活性降低是起重要作用的。
Protein C is a vitamin K-dependent protein in human plasma and is synthesized by the liver. The activated protein C has an antithrombotic effect due to the inactivation of factor V and factor VII and the increase of circulating plasminogen activator Caused by. Acquired protein C deficiency has been reported in chronic liver disease, adult respiratory distress syndrome, diffuse intravascular coagulation, postoperative surgery, etc. It appears that protein C plays an important role in regulating the balance between coagulation and fibrinolysis. The authors found that the level of C protein in hemodialysis patients was determined, suggesting a correlation between reduced activity of protein C and progressive renal failure. Among thrombophilia seen during nephropathy and uremia, protein C activity Reduce is important.