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测定了环丙沙星、头孢他啶、头孢米诺、氨曲南、亚胺培南／西司他丁和奈替米星在５ＭＩＣ药浓度下与金葡球茵、大肠杆菌作用１～２ｈ的体外抗生素后效应（ＰＡＥ）。抗菌药物的去除采用稀释法，细菌生长情况的监测采用菌落计数法。所测试的β－内酰胺类药物（氨曲南除外）对金葡球菌均有ＰＡＥ，对大肠杆菌仅亚胺培南／西司他丁有ＰＡＥ。环丙沙星、奈替米星对金葡球菌、大肠杆菌均产生ＰＡＥ。利用ＰＡＥ的特点可指导临床合理用药。
The effects of ciprofloxacin, ceftazidime, cefminoxime, aztreonam, imipenem / cilastatin and netilmicin were evaluated in vitro with 5-microgram drug concentration of E.coli and E.coli for 1-2 hours Post-antibiotic effect (PAE). Antibacterial drug use dilution method, bacterial growth monitoring using colony counting method. The tested beta-lactam drugs (except aztreonam) had PAE against Staphylococcus aureus and PAE against E. coli only imipenem / cilastatin. Ciprofloxacin, netilmicin Staphylococcus aureus, Escherichia coli have produced PAE. The use of PAE can guide the clinical rational use of drugs.