多系统萎缩(MSA)包括Shy—Drager综合征(SDS)、橄揽桥小脑萎缩(OPCA)、纹状体黑质变性(SND)以及临床及病理均不易分型的MSA。此外尚有齿状核—红核—苍白球—路易氏体萎缩症(CDPLA)等一些少见病、我科自1980年收治不易分型的MSA病例共11例,现报告如下: 资料本组男性8例,女例3例。年龄33～67岁,平均52.2岁,发病年龄29～66岁,平均48.1岁。发病至入院时间4月～10年,平均3.1年。11例均为隐袭性发病,缓慢逐渐进展,均无明确诱因。首发症状走路不稳、欠灵活7例,头晕2例,全身无力1例,肢体震颤1例。临床表现(见表)均见有少动、动作缓慢、肌强直、面部表情呆板、联合 Multiple system atrophy (MSA) includes Shy-Drager syndrome (SDS), olive tree cerebellar atrophy (OPCA), striatum substantia nigra degeneration (SND) and MSA that are clinically and pathologically not easily classified. In addition there are some rare cases of dentate nucleus - red nucleus - globus pallidus - Lewy bodies atrophy (CDPLA) and other rare cases, our department since 1980, easy to type MSA cases were treated in 11 cases, are as follows: 8 cases, 3 cases of female cases. Aged 33 to 67 years old, with an average of 52.2 years of age, age of onset 29 to 66 years, mean 48.1 years. The onset of admission to April to 10 years, an average of 3.1 years. Eleven cases were insidious onset, slow progress, no clear incentive. The first symptom of walking unsteady, less flexible in 7 cases, 2 cases of dizziness, generalized weakness in 1 case, limb tremor in 1 case. Clinical manifestations (see table) are seen less movement, slow movements, muscle rigidity, facial expression dull, the joint