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报告确诊肝硬化、肝功能失代偿期合并有MOF21例,其中死亡18例,病死率85.7%。衰竭器官4个以上者死亡率为100%。衰竭器官发生频率依次为肝、肾、消化道、脑、血液、肺、心。21例中有明显感染征象者15例,提示感染、内毒素(ET)可能为肝硬化并发MOF的主要原因。主要为自发性腹膜炎,胆系感染,肺部和泌尿系感染。严重肝硬化合并MOF预后很差,死亡率极高,临床上应高度重视,早期发现。处理强调综合治疗,其中以有效控制感染、减少内毒素的吸收尤为重要。
Report confirmed liver cirrhosis, decompensated liver function with MOF in 21 cases, of which 18 died, the mortality rate of 85.7%. Failure of more than 4 organs mortality was 100%. The frequency of failing organs followed by liver, kidney, digestive tract, brain, blood, lung, heart. Among the 21 cases, there were 15 cases with obvious signs of infection, suggesting that infection and endotoxin (ET) may be the main cause of complicated cirrhosis with MOF. Mainly for spontaneous peritonitis, gall bladder infection, lung and urinary tract infections. Severe cirrhosis complicated with MOF prognosis is poor, the mortality rate is extremely high, should pay close attention to the clinical, early detection. Treatment emphasizes comprehensive treatment, which is particularly important to effectively control infection and reduce endotoxin absorption.