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目的探讨可溶性CD40配体(sCD40L)、可溶性P-选择素(sP-selectin)和可溶性细胞间黏附分子-1(sICAM-1)在鼻咽癌患者血浆中的表达及临床意义。方法收集110名鼻咽癌患者和55名年龄和性别匹配的健康成人的血浆,用酶联免疫吸附法(ELISA)测定sCD40L、sP-selectin和sICAM-1在血浆中的表达。结果鼻咽癌患者血浆sCD40L、sP-selectin和sICAM-1含量明显高于对照组,颈淋巴结转移者高于非转移者,且sCD40L和sP-selectin在鼻咽癌患者治疗后的表达明显低于治疗前,而sICAM-1只在Ⅲ+Ⅳ期鼻咽癌患者治疗后的表达有下降。结论鼻咽癌患者血浆sCD40L、sP-selectin和sICAM-1存在高表达现象,并且sCD40L、sP-selectin和sICAM-1在鼻咽癌的转移和疗效判断上有一定的价值。
Objective To investigate the expression and clinical significance of sCD40L, sP-selectin and sICAM-1 in the plasma of patients with nasopharyngeal carcinoma. Methods The plasma of 110 nasopharyngeal carcinoma patients and 55 healthy adults aged and sex matched were collected. The expression of sCD40L, sP-selectin and sICAM-1 in plasma were detected by enzyme linked immunosorbent assay (ELISA). Results The plasma levels of sCD40L, sP-selectin and sICAM-1 in patients with nasopharyngeal carcinoma were significantly higher than those in the control group, and the rates of sCD40L and sP-selectin were significantly lower in patients with nasopharyngeal carcinoma than in those without metastasis Before treatment, sICAM-1 only decreased in patients with stage Ⅲ + Ⅳ NPC after treatment. Conclusion The expression of sCD40L, sP-selectin and sICAM-1 in the plasma of patients with nasopharyngeal carcinoma is highly expressed, and sCD40L, sP-selectin and sICAM-1 have some value in judging the metastasis and curative effect of nasopharyngeal carcinoma.