健康成人自愿受试者38例,随机分为6组,分别单次口服国产盐酸劳卡胺50、100、200mg和单次静注国产盐酸劳卡胺0.5、1.0、1.5mg/kg.结果表明,该药不良反应以中枢神经系统症状最明显,表现为睡眠障碍、头痛和头晕;心电图P—R、QRS问期均有延长趋势,但仍在正常范围内.以上改变具剂量相关性.血浓监测提示,峰血浓时上述改变最为显著.该药对血压、心率及血液生化、肝肾功能均无明显影响. Thirty-eight healthy volunteers were randomly divided into 6 groups, each receiving 50,100,200mg of domestic labicin hydrochloride and 0.5,1.0,1.5mg / kg of domestic labicin hydrochloride intravenously.The results showed that , The drug adverse reactions to the central nervous system symptoms were the most obvious, manifested as sleep disorders, headache and dizziness; electrocardiogram P-R, QRS ask period has an extension trend, but still within the normal range.The above changes with a dose-related Concentration monitoring tips, the peak of blood concentration was the most significant change in the drug on blood pressure, heart rate and blood biochemical, liver and kidney function had no significant effect.