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目的建立胸大肌部分移位重建屈肘功能动物模型,为进一步研究术后供体肌和受体肌的内部变化奠定基础。方法 42只成年SD大鼠随机分为7组:正常组;肌皮神经切断后1、2、4周组;胸大肌部分移位重建屈肘术后1、2、4周组。肌皮神经切断后行胸大肌部分移位重建屈肘术;称量肌湿重,计算肌湿重保持率。结果支配SD大鼠肱二头肌的肌皮神经与肱动脉肌支从该肌肌腹的内侧缘上部入肌;支配胸大肌的胸外侧神经和胸外侧血管从该肌止端深面出入。胸大肌可分为横部和斜部,后者足够长移位缝合至肱二头肌腱止端。胸大肌斜部移位重建屈肘功能术时不会伤及血管神经。切断肌皮神经后1~4周,肱二头肌色泽、肌块体积、湿重和湿重保持率持续下降,步态拖曳,觅食受限。胸大肌斜部移位重建屈肘术后1~4周,上述指标逐渐改善;胸大肌斜部色泽和肌块体积变化不大,肌湿重和湿重保持率下降仅在屈肘重建术后1周时有统计学意义。结论大鼠失肌皮神经后行胸大肌斜部移位重建屈肘功能术是可行的,它能改善肱二头肌萎缩,对供体肌本身仅造成一过性损伤。
OBJECTIVE: To establish an animal model of partial flexion and reconstruction of the pectoralis major muscle function and to lay a foundation for further study on the internal changes of the donor and recipient muscles. Methods Forty-two adult SD rats were randomly divided into 7 groups: normal group, 1, 2, 4 weeks after muscular cutaneous nerve transection; part of pectoralis major displaced and reconstructed 1, 2, 4 weeks after flexion. Muscle cut into the pectoralis major muscle partial displacement reconstruction elbow surgery; weighed muscle wet weight, muscle wet weight retention rate. Results The SD rats biceps brachii nerves and brachial artery branch from the medial margin of the muscle belly into the upper muscle; control the pectoralis major thoracic nerves and thoracic vessels from the deep end of the muscle end of access . Pectoralis major can be divided into horizontal and oblique, which is long enough to shift the suture to the biceps tendon only. Pectoralis major oblique shift reconstruction elbow flexion surgery will not hurt the vascular nerve. 1 ~ 4 weeks after cutting off the musculocutaneous nerve, biceps muscle color, muscle mass, wet weight and wet weight retention continued to decline, gait dragging, foraging restricted. Pectoralis major oblique shift 1 to 4 weeks after reconstruction of elbow flexion, the above indicators gradually improved; pectoralis major oblique color and muscle volume changes, muscle wet weight and wet weight retention decreased only in elbow reconstruction One week after surgery was statistically significant. Conclusion It is feasible to reconstruct the elbow flexion function after the denervated musculocutaneous nerve in the rat is transplanted. It can ameliorate the biceps atrophy and cause only a transient damage to the donor muscle itself.