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目的探讨不同胎龄早产儿早期凝血功能指标差异,为早产儿临床诊治提供依据。方法选取2015年1月-2016年1月该院出生的165例早产儿为研究对象,按照胎龄将其分为早期早产儿44例,中期早产儿50及晚期早产儿71例;另选取同期足月新生儿52例作为对照组;于出生后2 h内检测其凝血功能指标。比较各组患儿及产妇临床资料与凝血功能指标。结果3组不同胎龄早产儿凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及凝血酶时间(TT)比较,差异均无统计学意义(均P>0.05);PT、APTT 95th%以晚期早产儿略低于早期及中期早产儿,TT随周龄增大出现减小趋势,但差异无统计学意义(P>0.05);足月新生儿PT、APTT、TT较3组早产儿均显著下降(P<0.05),FIB则显著升高(P<0.05);4组产妇PT、APTT、FIB、TT比较差异均无统计学意义(均P>0.05)。结论与足月新生儿相比,早产儿存在早期凝血功能降低,检测PT、APTT、FIB、TT水平可以早期发现凝止血功能异常,为早产儿的早期干预、临床指导用药提供依据。
Objective To investigate the differences of coagulation function in early gestational age of preterm infants with different gestational age and provide evidence for the clinical diagnosis and treatment of premature infants. METHODS: A total of 165 preterm infants born in our hospital from January 2015 to January 2016 were selected as study subjects. According to their gestational age, 44 premature infants, 50 preterm infants and 71 premature infants were enrolled in this study. Fifty-two full-term newborns served as control group; coagulation function indexes were detected within 2 h after birth. The clinical data and coagulation indexes of children and maternal mothers in each group were compared. Results There were no significant differences in PT, APTT, FIB and TT between 3 groups with different gestational age (P > 0.05). The PT and APTT 95th% were lower in advanced preterm infants than those in early and middle preterm infants, while the TT decreased with increasing age, but the difference was not statistically significant (P> 0.05); full-term neonatal PT , APTT and TT were lower than those in the three groups (P <0.05) and FIB (P <0.05). There was no significant difference in PT, APTT, FIB and TT between the four groups (all P> 0.05). Conclusion Compared with full-term newborns, there is a decrease of early coagulation in premature infants. Detecting PT, APTT, FIB and TT levels can detect coagulation-hemostatic dysfunction early and provide basis for early intervention and clinical guidance of premature infants.