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丙型肝炎病毒(HCV)感染是慢性肝炎的主要病因之一。目前全球HCV感染者已经超过1.85亿,约70%进展为慢性感染。慢性HCV感染的不同结局取决于病毒和宿主双方面因素。研究表明,年龄、男性、饮酒和胰岛素抵抗(insulin resistance,IR)是CHC疾病进展的危险因素。近20年的研究表明,慢性HCV感染及IR存在相关性,慢性HCV感染可以引起肝脏及外周的IR,而IR又可以促进慢性HCV感染患者肝脏炎症及纤维化进展,并导致抗病毒治疗患者持续病毒学应答率下降。因此,对于慢性HCV感染与IR关系的研究,对于预测HCV慢性感染结局及防治疾病进展有重要意义,旨在抑制肝纤维化的发生及改善抗病毒治疗的疗效。
Hepatitis C virus (HCV) infection is one of the major causes of chronic hepatitis. At present, there are more than 185 million HCV infections in the world and about 70% of them have progressed to chronic infections. The different outcomes of chronic HCV infection depend on both the virus and the host. Studies have shown that age, men, alcohol consumption and insulin resistance (IRR) are risk factors for CHC disease progression. Nearly 20 years of research have shown that there is a correlation between chronic HCV infection and IR. Chronic HCV infection can cause liver and peripheral IR, and IR can promote the progress of liver inflammation and fibrosis in patients with chronic HCV infection and lead to persistence of antiviral therapy Virological response rate decreased. Therefore, the study on the relationship between chronic HCV infection and IR is of great significance in predicting the outcome of chronic infection of HCV and preventing the progression of the disease, so as to inhibit the occurrence of liver fibrosis and improve the efficacy of antiviral therapy.