论文部分内容阅读
目的观察甘精胰岛素(来得时)联合口服降糖药治疗2型糖尿病的临床疗效。方法对47例单用口服降糖药效果欠佳的2型糖尿病患者睡前(22时)加用甘精胰岛素分别测定治疗3个月前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹C肽、餐后2hC肽,血脂、体重。结果加用甘精胰岛素治疗3个月后,患者的FPG、2hPG、HbA1c较治疗前明显下降(P<0.01),餐后2hC肽较治疗前明显升高,其差异有统计学意义(P<0.01),而对血脂、体重指数影响不大。结论对单用口服药效果不佳的2型糖尿病,加用甘精胰岛素治疗效果显著。
Objective To observe the clinical efficacy of insulin glargine (dex) and oral hypoglycemic agents in the treatment of type 2 diabetes mellitus (T2DM). Methods 47 patients with type 2 diabetes mellitus who did not receive oral hypoglycemic agents were given fasting blood glucose (FPG) and 2 hours postprandial blood glucose (2hPG) before going to bed (22:00) and insulin glargine (3 g) , Glycosylated hemoglobin (HbA1c), fasting C-peptide, postprandial 2hC peptide, lipids, body weight. Results After treated with insulin glargine for 3 months, the levels of FPG, 2hPG and HbA1c in patients were significantly lower than those before treatment (P <0.01), and the levels of peptide 2h after meal were significantly higher than those before treatment (P < 0.01), while blood lipids, body mass index had little effect. Conclusions The effect of single oral medication on type 2 diabetes with glargine is significant.