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[目的]探讨胃炎饮对实验性胆汁反流性胃炎大鼠血浆6-酮-前列腺素F1α(6-Keto-PGF1α)和血栓素B2(TXB2)水平的影响。[方法]采用自制反流液灌胃建立实验性胆汁反流性胃炎大鼠模型,以多潘立酮为对照,观察胃炎饮对大鼠胃黏膜病理组织学和血浆6-Keto-PGF1α、TXB2水平的影响。[结果]模型组大鼠胃黏膜出现明显破损、脱落,黏膜下可见大量炎细胞浸润,大部分大鼠胃黏膜可见不典型增生和肠上皮化生,同时血浆6-Keto-PGF1α水平明显下降,TXB2水平明显上升(P<0.01);与模型组比较,各治疗组均可明显改善大鼠胃黏膜病理组织学变化,升高6-Keto-PGF1α水平,降低TXB2水平(P<0.01,<0.05)。[结论]胃炎饮可调节血浆6-Keto-PGF1α和TXB2水平,提高胃黏膜血流量,加强胃黏膜的黏液-碳酸氢盐屏障,减轻反流液对胃黏膜的损伤。
[Objective] To explore the effect of Weiyanyin on plasma 6-Keto-PGF1α and TXB2 levels in experimental rats with bile reflux gastritis. [Methods] A rat model of bile reflux gastritis was established by intragastric administration of self-made reflux fluid. With domperidone as control, the effect of Weiyanyin on the histopathology of gastric mucosa and levels of plasma 6-Keto-PGF1α and TXB2 were observed. . [Results] The gastric mucosa of the model group was obviously damaged and fell off, and a large number of inflammatory cells infiltrated under the mucosa. Most of the rats showed dysplasia and intestinal metaplasia in the gastric mucosa, and plasma 6-Keto-PGF1α levels decreased significantly. The level of TXB2 was significantly increased (P<0.01). Compared with the model group, the treatment group could significantly improve the pathological changes of gastric mucosa, increase the level of 6-Keto-PGF1α and decrease the level of TXB2 (P<0.01,<0.05). ). [Conclusion] Weiyanyin can regulate plasma 6-Keto-PGF1α and TXB2 levels, increase gastric mucosal blood flow, strengthen mucosal-bicarbonate barrier of gastric mucosa, and reduce the damage of gastric mucosa caused by reflux fluid.